May A Virus Cause Obesity?

What do you know about a virus called Adenovirus-36? Or a virus called SMAM-1? It is common knowledge that they are related to common chilly virus. Adenovirus-36 causes eye plus respiratory infections in humans.

What we learnt recently is these two viruses may cause fattening of animal and human cells. Research out of Louisiana State University indicates that obesity may be caused by these viruses.

Not all researchers agree with this finding. Steve Bloom, an obesity researcher at Hammersmith Hospital in London flatly refuses to believe that viruses are a common cause of obesity.

Nikhil Durundhar of LSU, who first showed that both these rogue viruses could make animals put on weight, discovered that the lab animals infected with all the virus spread it to their cage mates in 12 hours. So obesity could be infectious as well.

Magdalena Passarica isolated the stem cells from the fat extracted during the large volume liposuction atlanta. She then infected these tissue with Adrenovirus-36. Not only did the cells multiply but also became bloated along with fat. She presented her leads to September, 2007, Boston at the United states Chemical Society. Further more, it is interesting to note that exposure of individual stem cells to other viruses had no such effect.

The study simply by Dhurundhar and Pasarica involved obese and non-obese people of each genders in the age group of 29-45. 360 obese people and a hunread forty two thin people participated. Their study also showed that viruses fattened the cells but also decreased the bad cholesterol and triglycerides in the bodies.
If it can be proven without any doubt that this is indeed the case, then we may have a remedy for obesity.
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There are two ways to do this. Vaccinate against the Adenovirus-36 is a sure way. Or you can kill it with no- viral drugs. Passarica of LSU proved that Cidofovir, an antiviral drug, is effective anti – dose to Adrenovirus-36 by experimenting upon fatty cells of rats.

The particular obesity is a world wide problem. It really is increasing at an alarming rate amongst people of all ages, genders, races plus countries. When the Body Mass Index (BMI) is greater than 30 kg/square meter in a person, that person will be classified as obese. The officially accepted reasons of obesity are genetics, behaviour and endocrine. So far the infectious etiology has not been discovered fully.
Other viruses involved in the harmful of animal cells are Dog Distemper Virus, Rous associated Computer virus -7, Borna Disease virus plus a Scrapie Agent.

It was later documented by the same group of researchers through LSU in the International Journal associated with Obesity, January, 2007 that “The in vitro and ex vivo studies show that Ad-36 modulates adipocyte differentiation, leptin production and glucose metabolism. Whether such a modulation plays a part in enhanced adipogenesis and consequent adiposity in Ad-36 infected animals or even humans needs to be determined”.

In an article “Could Virus Contribute to Weight gain? ” in the same journal, A Vasilakopoulou and C W le Roux (Hammersmith, London), report in Apr, 2007, “More work is however required to elucidate the mechanisms of weight gain after viral infection. Within the mean time, discounting viruses being a contributing factor to obesity would certainly deprive us of a potential new avenue of investigating and treating the ever increasing epidemic of obesity. Obesity is currently thought of as a way of living disease, but two decades ago so was peptic ulcer disease before the groundbreaking work by Warren plus Marshall on Helicobacter pylori”.

Close to 100 million Americans are affected by being overweight. To alleviate the pain of such large number of people, it is worth while to extend research to find more robust evidence intended for viral causes which may lead to cures other than liposuction.

The study of viral infection as a cause of obesity was done on animals and humans. The results were published in respectable journals. It is quite clear that infections can not be ruled out as a cause of harmful in humans. But how viruses fatten the cells is still a virgin mobile track to be explored. Once the mechanism is understood, skeptics may be converted. That is how science progresses. We are able to guess what might happen when infections infect cells. They might react with all the surface of the cell and boost the volume. Conversely, the viruses might enter the cell and affect the core and the way energy is spent. Virus may affect a particular organ without causing damage to other internal organs. There are instances in literature exactly where this happened. We may go back to 1916-1917 when a viral outbreak occurred. Constantin von Economo reported a condition that will found damage in substantia nigra without any damage to other portions from the brain.